睾丸混合性生殖细胞瘤的诊治

Clinical diagnosis and treatment of mixed testicular germ cell tumor

摘要:

目的 探讨睾丸混合性生殖细胞瘤的临床特征及治疗策略.方法 回顾性分析1例睾丸混合性生殖细胞瘤患者病史资料并结合相关文献讨论睾丸混合性生殖细胞瘤的生物学行为、治疗及随访策略.患者为22岁青年男性,发现左侧睾丸肿物2个月余,AFP 200.43ng/mL、β-HCG 554.17 mlU/mL,阴囊彩超及CT提示左侧睾丸实性占位,考虑肿瘤可能性大.结果 术中行快速冰冻检查提示(左侧)睾丸胚胎性癌,不能排除恶性Sertoli细胞瘤；行左侧睾丸附睾切除术,术后病理检查明确为(左侧睾丸)混合性生殖细胞瘤.结论 睾丸混合性生殖细胞瘤极其少见,恶性度较高,宜早诊断,及时手术并辅以放化疗,以延长生存期.

Abstract:

Objectives To inquire into the clinical characteristics and the clinical treatment of the mixed testicular germ cell tumor.Methods The clinical data of one case on mixed testicular germ cell tumor was analyzed retrospectively and the relevant literature was reviewed.A 22-year-old male suffered testicular mass for two months,AFP 200.43ng/mL,β-HCG 554.17 mlU/mL,Color Doppler Ultrasound in scrotum and CT indicate the left testis was an occupying lesion,and the possibility of testis tumor was very large.Results Frozen-section diagnosis proved it to be an embryonal carcinoma,but the Sertoli cell tumor must be taken into account.The pathological diagnosis after orchidectomy finally confirms it to be a mixed testicular germ cell tumor.Conclusions Mixed testicular germ cell tumor is rare and with a high degree of malignancy.Surgical operation and adjuvant therapy with radiation therapy and chemotherapy in time is of very importance so as to prolong survival time of the patients.