血清抗苗勒管激素和血清抑制素B水平对隐睾症患者睾丸功能评价的意义

The significance of serum anti-niullerian hormone and serum inhibin B in the evaluation of testicular function of children with cryptorchidism

摘要:

目的探讨血清抗苗勒管激素(AMH)和血清抑制索B(INH-B)对隐睾症患者睾丸功能评价的意义。方法采用酶免疫吸附试验(ELISA)检测2018年11月至2019年7月本院收治的53例隐翠症患儿的INH-B及AMH水平(设为病例组),其中单侧隐翠患儿31例(右侧隐睾19例,左侧隐睾12例),双侧隐睾患儿22例。年龄(55.0±3.5)个月。另随机选取51例正常男性儿童作为对照组,年龄(54.6±2.7)个月。两组在术前及术后6个月时随访测定血清AMH和INH-B以及相关发育参数。分析比较各组之间和手术前后血清激素水平差异。结果两组除睾丸体积参数外的其余生殖器发育相关参数比较,差异均有统计学意义(P<0.05)。单侧隐睾与双侧隐翠患者的血清INH-B值[(71.36±6.80)pg/mLvs.(68.08±7.10)pg/mL]和AMH值[(115.44±8.90)ng/mL vs.(110.32±9.10)ng/mlL]比较,差异有统计学意义(P<0.05)。两组术前检测血清INH-B值,分别是(69.97±7.50)pg/mL和(75.15±6.30)pg/mL,差异有统计学意义(P<0.05)。两组术前检测血清AMH值,分别是(113.32±9.30)ng/ml,(127.80±8.7)ng/mL,差异均有统计学意义(P<0.05)。病例组术后6个月随访时检测血清INH-B值为(72.81±6.80)pg/mL,血清AMH值为(119.79 ± 7.3)ng/mL;与术前血清AMH.INH-B水平比较,差异均有统计学意义(P<0.05)。结论血清AMH和INH-B水平可作为评估隐睾症患者评估睾丸功能的可靠指标,并且能评价睾丸固定术后睾丸功能恢复情况。

Abstract:

Objective To investigate the signifcance of serum anti-mullerian hormone(AMH)and serum inhibin B(INH-B)in the evaluation of testicular function of children with cryp-torchidism.Methods From November 2018 to July 2019,53 cases of INH-B and AMH levels in children with cryptorchidism were detected by immunosorbent assay(ELISA),ineluding 31 children with unilateral cryptorchidism.There were 19 ceases of right cryptorchidism,12 cases of left cryp-torchidism,and 22 cases of bilateral eryptorchidism.The average age was(55.0+3.5)months.An-other 51 normal male children were randomly selected as the control group,with an average age of(54.6+2.7)months.Serum AMH and INH-B,and related developmental paramelers were measured in both groups before and 6 months after surgery.The differences in serum hormone levels between groups and before and after surgery were analyzed and compared.Results Children with cryptorechid-ism and control group were measured for genital development parameters before surgery,including pe-nis length,penis circumference and testicular volume.There were staistically significant dfferences between the cryptorchidism group and the control group except the testicular volume parameters.Uni-lateral cryptorchidism and bilateral cryptorchidism were compared with serum INH-B and AMH values,unilateral group(71.36±6.80)pg/ml.vs.bilateral group(68.08±7.10)pg/mL,unilateral group(115.44±8.90)ng/mL vs.double-sided group(110.32+9.10)ng/mL,the data of the two indicators in the unilateral group were significantly higher than the bilateral group,and the difference was saistically signifcant(P<0.05).The serum INH-B values of the eryptorchidism group and the control group were(69.97±7.50)pg/mL,(75.15±6.30)pg/mL,respectively.The difference was staistically signifcant(P<0.05).The serum AMH values of cryplorchidism group and control group were(113.32+9.30)ng/ml.and(127.80±8.70)ng/mL,respectively.The differences were statistically significant(P<0.05).The serum INH-B value was(72.81+6.80)pg/mL in the cryptorchidism group at 6 months follow-up.The serum AMH value of the ery plorchidism group was(119.79+7.30)ng/mL at 6 months follow-up.There were significant differences in serum AMH and INH-B levels before operation.Conclusions Serum AMH and serum INH-B levels can be used as a reliable indicator for assessing testicular function in patients with cryptorchidism,and can evaluate tes-ticular function recovery after testicular fixation.