血清鸢尾素、血小板因子4及低氧诱导因子-1α水平在膀胱癌中的作用

The diagnosis and prognosis of serum irisin,platelet factor 4 and hypoxia inducible factor-1α in bladder cancer

摘要:

目的 探讨血清鸢尾素、血小板因子4（PF4）及低氧诱导因子-1α（HIF-1α）水平在膀胱癌中的诊断及预后作用。方法 选择2018年10月至2020年6月于本院确诊并行膀胱癌根治术治疗的膀胱癌患者75例（疾病组），并随机选择同时期健康体检者72例（健康组）。收集受试者的一般资料、手术相关情况及血清鸢尾素、PF4、HIF-1α水平，对血清鸢尾素、PF4及HIF-1α水平与膀胱癌发生及预后的相关性进行分析。结果 疾病组患者的血清鸢尾素、PF4及HIF-1α水平均高于健康组（均P<0.05）。血清鸢尾素、PF4及HIF-1α在膀胱癌诊断方面具有较高的灵敏度（63.25%、78.30%、84.96%）和特异度（88.52%、87.45%、91.02%）（均P<0.05）。75例膀胱癌患者中39例患者预后良好、36例患者预后不良。单因素结果显示，两组年龄、肿瘤直径、病理分级、临床分期、肿瘤转移、血清鸢尾素、PF4、HIF-1α水平比较，差异具有统计学意义（P<0.05）；肿瘤转移、血清鸢尾素、PF4、HIF-1α水平是膀胱癌预后的独立影响因素（P<0.05）；多元线性逐步回归分析结果显示，血清鸢尾素、HIF-1α水平是影响膀胱癌患者预后的影响因子（P<0.05）。血清鸢尾素、PF4及HIF-1α在膀胱癌预后评估中具有较高灵敏度（70.12%、89.11%、86.52%）和特异度（78.96%、82.23%、91.07%）（均P<0.05）。结论 血清鸢尾素、HIF-1α、PF4水平在膀胱癌患者中上调，高水平的血清鸢尾素、HIF-1α及PF4与膀胱癌术后的预后不良相关，可作为患者预后的预测因子。

Abstract:

Objective?? To investigate the diagnosis and prognosis of serum irisin, platelet factor 4 (PF4) and hypoxia inducible factor-1α(HIF-1α) in bladder cancer.Methods?? From October 2018 to June 2020, 75 patients with bladder cancer(disease group) who were diagnosed in our hospital and undergoing radical bladder cancer treatment were selected, and 72 patients with healthy physical examination at the same time (healthy group) were randomly selected. Subjects' general information, surgery-related information, and serum irisin, PF4, HIF-1α levels were collected, and the correlation between serum irisin, PF4, HIF-1α and the occurrence and prognosis of bladder cancer was statistically analyzed.Results?? The levels of serum irisin, PF4 and HIF-1α in the disease group were higher than those in the healthy group (P<0.05), Serum irisin, PF4 and HIF-1α had higher sensitivity (63.25%, 78.30%, 84.96%) and specificity (88.52%, 87.45%, 91.02%) in the diagnosis of bladder cancer (P<0.05). Tumor metastasis, serum irisin, PF4, and HIF-1α levels are independent prognostic factors (P<0.05); the results of multiple linear regression analysis show that serum irisin and HIF-1α are influential factors affecting the prognosis of patients with bladder cancer (P<0.05).? Serum irisin, PF4 and HIF-1α had high sensitivity (70.12%, 89.11%, 86.52%) and specificity (78.96%, 82.23%, 91.07%) in the prognostic assessment of bladder cancer (P<0.05).Conclusions?? Serum irisin, HIF-1α, and PF4 are up-regulated in patients with bladder cancer and are of great value in the diagnosis of bladder cancer; high levels of serum irisin, HIF-1α, and PF4 are associated with poor prognosis of patients with bladder cancer and can be used as predictors of patient prognosis under confounding factors, only serum irisin and HIF-1α can be used as sensitive factors to predict the prognosis of patients with bladder cancer.