腹腔镜膀胱根治性切除术联合吡柔比星治疗膀胱肿瘤的效果及对血清CA125、α-FR水平的影响

Laparoscopic radical cystectomy combined with pirarubicin in the treatment of bladder tumors and its effect on serum CA125 and α-FR levels

摘要:

目的 分析腹腔镜膀胱根治性切除术联合术后吡柔比星治疗膀胱肿瘤的效果及对血清CA125、α-FR水平的影响。方法 将本院2016年12月至2019年10月间收治的80例膀胱癌患者随机分为观察组和对照组，每组40例。对照组采用腹腔镜膀胱根治性切除术治疗，观察组采用腹腔镜膀胱根治性切除术联合术后吡柔比星治疗；记录两组患者的术后排气时间、术后住院时间、引流管拔除时间及术后3个月不良反应发生情况；随访1年以上，记录患者的术后复发情况及术前、术后半年、术后1年时检测患者的血清α-FR和CA125水平。结果 观察组的术后排气时间、术后住院时间和引流管拔除时间均明显低于对照组（均P<0.01）；两组的治疗并发症比较，差异无统计学意义（5% vs. 10%，P>0.05）；观察组治疗1年内的复发率明显低于对照组（P=0.007）；术后半年和术后1年时观察组的血清α-FR和CA125水平均明显低于对照组，差异有统计学意义（均P<0.001）。结论 腹腔镜膀胱根治性切除术联合术后吡柔比星治疗膀胱肿瘤可有效改善患者的预后质量，降低血清CA125、α-FR水平。

Abstract:

Objective?? To analyze the effect of laparoscopic radical cystectomy combined with pirarubicin in the treatment of bladder tumors and the effect on serum CA125 and α-FR levels.Methods?? Eighty patients with bladder cancer admitted to our hospital from December 2016 to October 2019 were randomly divided into observation group and control group, 40 cases in each group. The control group was treated with laparoscopic radical cystectomy, and the observation group was treated with laparoscopic radical cystectomy resection combined with pirarubicin treatment; the postoperative exhaust time, postoperative hospital stay, drainage tube removal time of the two groups of patients and the occurrence of adverse reactions 3 months after the operation were recorded. Patients were followed up for more than 1 year, and postoperative recurrence was recorded. Before operation, half a year after operation, and one year after operation, the levels of α-FR and CA125 in the blood of patients were measured.Results?? The postoperative exhaust time, postoperative hospital stay and drainage tube removal time of the observation group were significantly lower than those of the control group, and the difference was statistically significant(P<0.001); there was no significant difference in treatment complications between the observation group and the control group(5% vs.10%，P>0.05); the recurrence rate of the observation group within one year of treatment was significantly lower than that of the control group(P=0.007); the blood levels of α-FR and CA125 in the observation group were significant at half a year after surgery and one year after surgery lower than the control group, and the difference was statistically significant(P<0.001).Conclusions?? Laparoscopic radical cystectomy combined with pirarubicin can effectively improve the prognosis of patients with bladder tumors and reduce serum CA125 and α-FR levels.