中性粒细胞百分比与白蛋白比值与冠状动脉狭窄程度的相关性

Correlation analysis between neutrophil percentage-to-albumin ratio and degree of coronary artery stenosis

摘要:

目的 探究中性粒细胞百分比与白蛋白比值(neutrophil percentage-to -albumin rato, NPAR)与冠状动脉狭窄程度的关系。方法 选取2020年11月至2021年7月于锦州市中心医院接受冠状动脉造影(coronary angiography, CAG)的患者406例,根据CAG结果将其分为冠心病组(322例)和非冠心病组(84例)。采用Gensini积分评价冠状动脉狭窄程度;采用多因素Logistic回归分析冠心病的独立影响因素;采用Spearman相关分析Gensini积分与NPAR的相关性;通过受试者工作特征(receiver operating characteristic, ROC)曲线评估NPAR对冠心病的预测价值。结果 年龄、性别、高敏C反应蛋白、NPAR是冠心病的独立影响因素;Gensini积分与NAPR呈正相关(r=0.364,P<0.01);ROC曲线下面积为0.687(95%CI 0.632~0.741,P<0.05),NPAR截断值为1.6128,敏感度为50.3%,特异度为85.7%。结论 NPAR与冠状动脉狭窄程度正相关,对冠心病有一定的预测价值。

Abstract:

Objective To explore the relationship between neutrophil percentage-to-albumin ratio(NPAR)and the degree of coronary artery stenosis.Methods A total of 406 patients who underwent coronary angiography(CAG)in Jinzhou Central Hospital from November 2020 to July 2021 were selected.They were divided into the non-CHD group(84 cases)and the CHD group(322 cases)as the CAG result.Gensini score was used to evaluate the degree of coronary artery stenosis.The independent risk factors for coronary heart disease and the correlation between Gensini score and NPAR were evaluate by Multivariate Logistic regression analysis and Spearman correlation analysis,respectively.Receiver operating characteristic(ROC)curve was drawed to assess the predictive value of NPAR for coronary heart disease.Results The independent risk factors for coronary heart disease are age,gender,high-sensitivity C-reactive protein,NPAR.Gensini score was positively correlated with NPAR(r=0.364,P<0.01);the areas under curve of the ROC curve was 0.687(95%CI 0.632-0.741,P<0.05),and the cutoff value,sensitivity,specificity of NPAR were 1.6128,50.3%,and 85.7%,respectively.Conclusion NPAR is positively correlated with the coronary artery stenosis degree,which has certain predictive value for coronary heart disease.