血浆致动脉粥样硬化指数与非酒精性脂肪性肝病的相关性

Correlation analysis between atherogenic index of plasma and nonalcoholic fatty liver disease

摘要:

目的 探讨血浆致动脉粥样硬化指数(AIP)与非酒精性脂肪性肝病(NAFLD)的关系。方法 选取四川大学望江医院健康体检中心2020年5月-2021年5月行彩色超声初次诊断为NAFLD且未经过药物治疗的160例体检者作为NAFLD组,随机选取160例同期年龄及性别匹配的健康体检者作为对照组;记录两组的年龄、身高、体重、血压和体质量指数(BMI)并对两组体检者进行血脂检测,计算AIP。比较两组体检者各项指标的差异。使用Logistic回归分析NAFLD发病的相关因素。受试者工作特征(ROC)曲线评价AIP对NAFLD的诊断价值。结果 NAFLD组与对照组之间除身高差异无统计学意义外,其余各指标差异均有统计学意义。AIP(OR=2.070,95%CI:1.785~2.732,P<0.01)和BMI(OR=1.46,95%CI:1.172~1.819,P<0.01)为 NAFLD 发病的危险因素。AIP判断NAFLD的效能AUC=0.899(Z=13.233,P<0.01), 截断值为1.896(95%CI:0.836~1.943), 敏感度为82.93%,特异性为88.10%。结论 AIP与NAFLD之间有较强的相关性,AIP可作为NAFLD罹患风险的筛查指标。

Abstract:

Objective To investigate the correlation between atherogenic index of plasma(AIP)and nonalcoholic fatty liver disease(NAFLD).Methods Totally 160 patients who admitted to Health Checkup Center,Wangjiang Hospital,Sichuan University from May 2020 to May 2021 were enrolled,those patients underwent color doppler ultrasound and were initially diagnosed as NAFLD without drug therapy(NAFLD group),meanwhile,selected concurrent 160 age-and sex-matched controls(control group).The recorded data included age,height,weight,blood pressure,body mass index(BMI);blood lipid tests were performed in groups to calculate the AIP.The difference indicators of two groups were compared,NAFLD-related factors were performed in Logistic regression analysis,receiver operating characteristic(ROC)curve was used to evaluate the diagnostic value of AIP for NAFLD.Results Except for stature,differences in the other indicators of two groups were statistically significant.The risk factors for NAFLD were AIP(OR=2.070,95%CI:1.785-2.732,P<0.01)and BMI(OR=1.46,95%CI:1.172-1.819,P<0.01).The ROC curve of diagnostic index of AIP for NAFLD showed that the areas under curve(AUC),cut-off value,sensitivity and specificity were 0.899(Z=13.233,P<0.01),1.896(95%CI:0.836-1.943),82.93%and 88.10%,respectively.Conclusion Strong correlation were found between AIP and NAFLD,AIP can take on the role of screening indicator for the risk of NAFLD.