145例弥漫性大B细胞淋巴瘤患者静脉血栓栓塞发生率及危险因素分析

Analysis of the incidence and risk factors for venous thromboembolism in 145 patients with diffuse large B-cell lymphoma

摘要:

目的 探讨145例弥漫性大B细胞淋巴瘤(DLBCL)患者静脉血栓栓塞(VTE)发生率及危险因素。方法 选取2016年5月-2019年8月收治的DLBCL患者145例,依据深静脉血栓超声诊断结果分为VTE组(22例)和无VTE组(123例)。采用多因素logistic回归分析DLBCL患者发生VTE的危险因素,及两组复发率、无复发生存率、总体生存率差异。结果 静脉置管、34个疗程化疗未完全缓解(non-CR)、D-二聚体≥1.44 μg/ml是VTE的独立危险因素(OR=5.143、9.000、16.514,P<0.05),体能评分(PS评分) ≥2分为保护因素(OR=0.170,P<0.05);两组复发率、无复发生存率、总体生存率比较差异无统计学意义(P>0.05)。结论 静脉置管、34个疗程化疗non-CR、D-二聚体≥1.44 μg/ml均为DLBCL患者发生VTE的独立危险因素,PS评分≥2分为保护因素。

Abstract:

Objective To explore the incidence and risk factors for venous thromboembolism(VTE)in 145 patients with diffuse large B-cell lymphoma(DLBCL).Methods Totally 145 DLBCL patients admitted to our hospital from May 2016 to August 2019 were selected and divided into a VTE group(n=22)and a non-VTE group(n=123)as the results in ultrasonography for VTE.Multivariate Logistic regression was used to analyze the risk factors for VTE in DLBCL patients,as well as the difference of recurrence rate,recurrence-free survival rate,and overall survival rate between groups.Results The independent risk factors for VTE were intravenous catheterization,non-complete remission(non-CR)after 3-4 courses of chemotherapy,D-dimer level≥1.44μg/ml(OR=5.143,9.000,16.514,P<0.05).But performance status(PS)score≥2 was considered a protective factor(OR=0.170,P<0.05);there was no significant difference in recurrence rate,recurrence-free survival rate,and overall survival rate between groups(P>0.05).Conclusion Independent risk factors for VTE in DLBCL patients were Intravenous catheterization,non-CR after 3-4 courses of chemotherapy,D-dimer≥1.44μg/ml,and protective factor for VTE is PS score≥2.