冷冻疗法预防紫杉醇化学治疗所致周围神经病变

摘要:

紫杉醇化学治疗(以下简称“化疗”)所致周围神经病变(chemotherapy-induced peripheral neuropathy,CIPN)是化疗过程中常见的并发症，严重影响患者的生活质量。冷冻疗法在预防紫杉醇CIPN中的作用日益显现，但在临床应用中关于冷冻疗法的最佳实施策略仍存在许多争议。冷冻疗法通过降低四肢皮肤温度，减少局部血流量，降低化疗药物在肢端的累积量，从而达到预防CIPN的目的。其中，非恒温冷冻疗法简便易行，但降温效果不稳定，患者耐受性有限，而恒温冷冻疗法能够提供更稳定、更舒适的降温环境，并在多项研究中显示出较好的预防效果，但恒温冷冻疗法设备较笨重，且经济成本较高，限制了其在临床实践中的广泛应用。总结当前冷冻疗法在预防CIPN方面的主要研究结果，提出未来的研究方向，有利于冷冻疗法的不断改进和优化，为CIPN的预防和治疗提供有效手段，为患者带来更好的生活质量。

Abstract:

Paclitaxel chemotherapy-induced peripheral neuropathy (CIPN) is a common complication during chemotherapy and seriously affects patients’ quality of life. The role of cryotherapy in preventing paclitaxel CIPN is increasingly evident, but there are still many controversies regarding the optimal implementation strategy of cryotherapy in clinical practice. Cryotherapy works by reducing the skin temperature of the limbs, decreasing local blood flow, and reducing the accumulation of chemotherapy drugs at the limb ends to prevent CIPN. Among them, non-constant temperature cryotherapy is simple and easy to perform, but its cooling effect is unstable, and patients have limited tolerance. Constant temperature cryotherapy can provide a more stable and comfortable cooling environment and has shown better preventive effects in multiple studies. However, the equipment for constant temperature cryotherapy is bulky, and the economic cost is high, limiting its widespread application in clinical practice. Summarizing the main research results of cryotherapy in preventing CIPN and proposing future research directions will facilitate the continuous improvement and optimization of cryotherapy, providing effective means for the prevention and treatment of CIPN and improving patients’ quality of life.