地塞米松联合右美托咪定对初产妇剖宫产术后痛阈、麻醉药量及抑郁症的影响

Effects of dexamethasone combined with dexmedetomidine on pain threshold, anesthetic usage and depression in puerpera after cesarean section

摘要:

目的研究地塞米松联合右美托咪定静脉镇痛对初产妇剖宫产术后痛阈、麻醉药量及抑郁症的影响。 方法选取初产妇100例,随机分为对照组(n＝50)和联合用药组(n＝50),对照组在常规治疗上加用右美托咪定,联合用药组在常规治疗上联合使用地塞米松与右美托咪定,两组均采用爱丁堡产后抑郁量表(EPDS)对产妇术后抑郁状态进行测定,使用视觉模拟评分法(VAS)评估镇痛效果,比较两组不良反应发生率、产后24 h内镇痛泵按压次数及麻醉药量。 结果联合用药组产后1周和6周EPDS评分、产后不同时间VAS评分均明显低于对照组(P＜0.05)。联合用药组产后24 h内镇痛泵按压次数及麻醉药量均明显少于对照组(P＜0.05)。联合用药组不良反应发生率明显低于对照组(P＜0.05)。 结论地塞米松联合右美托咪定在初产妇行剖宫产术后能够取得较为满意的镇痛效果,安全性高,值得临床进一步推广应用。

Abstract:

To study the effects of dexamethasone combined with dexmedetomidine on pain threshold, anesthetic usage and depression of puerpera after cesarean section. Methods100 cases of primipara were selected and randomly divided into control group (n＝50) and combination medication group (n＝50). The control group received the conventional treatment with right beautiful mi set, observation group received the conventional treatment combined with dexamethasone and right beautiful mi set, adopting the Edinburgh postnatal depression scale (EPDS) to determine postnatal depression state, using visual analogue scale (VAS) to evaluate analgesic effect, the incidence of adverse reactions, postpartum analgesia pump pressure frequency and drug use within 24 h of two groups. ResultsEPDS scores one week and six weeks after delivery and VAS score in different postpartum time of the combination medication group were significantly lower than those of the control group. The number of analgesic pump press are and the amount of anesthesia in 24 h in the combination medication group were significantly less than those in the control group. The incidence of adverse reactions in the combination group was significantly lower than that in the control group (P＜0.05). ConclusionDexamethasone combined with dexmedetomidine in primipara after cesarean section can achieve satisfactory analgesic effect, high safety, worthy of further clinical application.