非小细胞肺癌患者外周血CD8+CD39+T细胞水平及临床意义

Expression and clinical significance of peripheral blood CD8+CD39+T cells in patients with non-small cell lung cancer

摘要:

目的探讨非小细胞肺癌(NSCLC)患者外周血CD8⁺CD39⁺T细胞水平及临床意义。方法选取60例NSCLC患者为NSCLC组,60例健康人群为对照组。检测两组外周血CD8⁺CD39⁺T细胞水平,分析NSCLC患者外周血CD8⁺CD39⁺T细胞水平与其临床特征和预后的关系。结果NSCLC组外周血CD8⁺CD39⁺T细胞水平显著高于对照组(P＜0.05)。肿瘤直径＞3 cm、低分化、TNMⅢ期的NSCLC患者外周血CD8⁺CD39⁺T细胞水平高于肿瘤直径≤3 cm、中高分化、TNMⅠ~Ⅱ期的患者(P＜0.05)。CD8⁺CD39⁺T细胞高水平组术后1年肿瘤无进展生存率及无进展生存期均低于低水平组(P＜0.05)。TNM分期、外周血CD8⁺CD39⁺T细胞水平是NSCLC患者预后的影响因素(P＜0.05)。结论CD8⁺CD39⁺T细胞在NSCLC患者外周血中呈高水平,且与临床病理特征及预后关系密切,可作为患者病情和预后的评估指标。

Abstract:

To investigate the expression and clinical significance of peripheral blood CD8⁺CD39⁺T cells in patients with non-small cell lung cancer (NSCLC). Methods60 patients with NSCLC were selected as the NSCLC group, and 60 healthy people were selected as the control group. Peripheral blood CD8⁺CD39⁺T cell level was detected in both groups, and the relationship between peripheral blood CD8⁺CD39⁺T cell level and clinical characteristics of NSCLC patients was analyzed. All NSCLC patients were followed up after surgery to analyze the relationship between peripheral blood CD8⁺CD39⁺T cell level and prognosis. ResultsThe peripheral CD8⁺CD39⁺T cell level in NSCLC group was significantly higher than that in the control group (P＜0.05). The level of CD8⁺CD39⁺T cells in peripheral blood of patients with low differentiation, stage Ⅲ or tumor diameter ＞3 cm was higher than that of patients with medium and high differentiation, stage Ⅰ~Ⅱ or tumor diameter ≤3 cm (P＜0.05). The progression-free survival rate 1 year after operation of patients in CD8⁺CD39⁺T high level group were lower than those in low level group (P＜0.05). TNM stage and peripheral blood CD8⁺CD39⁺T cell level were prognostic factors of NSCLC patients (P＜0.05). ConclusionThe CD8⁺CD39⁺T cells are highly expressed in the peripheral blood of patients with NSCLC, and are correlated with clinicopathological features and prognosis, which can be used as an indicator for evaluating the condition and prognosis of patients.