双歧杆菌四联活菌片联合四联疗法对HP阳性胃溃疡患者血清TGF-β1、G17、PGI的影响

Effect of Bifidobacterium tetralogy combined with quadruple therapy on serum TGF-1, G17, and PGI in patients with HP-positive gastric ulcer

摘要:

目的探讨双歧杆菌四联活菌片联合四联疗法对幽门螺旋杆菌(HP)阳性胃溃疡患者血清转化生长因子-β1(TGF-β1)、胃泌素17(G17)、胃蛋白酶原I(PGI)的影响。 方法选取HP阳性胃溃疡患者98例,随机均分为对照组和联合组。对照组采用四联疗法,联合组采用双歧杆菌四联活菌片联合四联疗法治疗。比较两组临床疗效、胃黏膜组织学评分、血清TGF-β1、PGI、G17、胃动素(MTL)、不良反应等情况。 结果联合组治疗总有效率高于对照组(P＜0.05)。与治疗前比较,治疗后两组胃黏膜组织学各项评分、TGF-β1、G17、PGI均降低,MTL升高,且联合组较对照组更为显著(P＜0.05)。联合组不良反应总发生率低于对照组(P＜0.05)。 结论双歧杆菌四联活菌片联合四联疗法治疗HP阳性胃溃疡患者疗效满意,可调节胃肠激素水平,安全性良好,具有临床应用价值。

Abstract:

To explore the effect of bifidobacterium quadruple viable tablet combined with quadruple therapy on serotransforming growth factor-1 (TGF-1), gastrin 17 (G17), and pepsinogen I (PGI) in patients with H.pylori (HP)-positive gastric ulcer. Methods98 patients with HP positive gastric ulcer were randomly divided into control group and combined group. The control group was treated with tetrad therapy, and the combined group was treated withtetrad therapy combined with bifidobacterium quadruple viable tablet. The clinical efficacy, gastric mucosal histological score, serum TGF-1, PGI, G17, gastrin (MTL), and adverse effects were compared between the two groups. ResultsThe total effrctiverate of the combination group was higher than control group (P＜0.05). Compared with pre-treatment, the gastric mucosal histology scores, TGF-1, G17, and PGI were decreased,and MTLwasincreased, and the combination group was more significant than control group (P＜0.05). The overall incidence of adverse effects in the combination group was lower than that in the control group (P＜0.05). ConclusionBifidobacterium quadruple viable tablet combined with quadruple therapy has a satisfactory curative effect in the treatment of HP-positive gastric ulcer, and can regulate the level of gastrointestinal hormones, with good safety and clinical value.