丙戊酸钠对青春期癫癎女孩垂体促性腺激素影响的研究

Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy

摘要:

目的：探讨丙戊酸钠(VPA)对青春期癫癎女孩垂体促性腺激素水平及垂体促性腺轴的影响。方法：选择青春期癫癎女孩23例，年龄8~14岁，给予VPA治疗1年，观察其用药前、用药后3月、6月、12月的垂体促性腺激素水平，包括雌二醇、卵泡刺激素、黄体生成素、泌乳素及睾酮。结果：VAP治疗1年中，患儿雌二醇、卵泡刺激素、黄体生成素、泌乳素水平差异均无统计学意义；但是治疗12个月时，患儿的睾酮水平（0.4±0.3 ng/mL）比未用药（0.7±0.4 ng/mL）时及用药3个月时（0.7±0.4 ng/mL）明显降低（P＜0.05）。结论：青春期癫癎女孩应用VPA治疗1年后未出现雄激素增高，VPA 仍是用于治疗青春期癫癎女孩的理想选择。

Abstract:

OBJECTIVE: To study the effects of valproate sodium (VPA) on the level and axle of pituitary gonadotropin in adolescent girls with epilepsy. METHODS: Twenty-three adolescent girls with epilepsy aged from 8 to 14 years were treated with VPA for 1 year. The levels of serum pituitary gonadotropin including estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin and testosterone were measured before treatment and 3 months, 6 months and 1 year after treatment. RESULTS: The serum levels of estradiol, follicle-stimulating hormone, luteinizing hormone and prolactin in the children with epilepsy were not significantly different during the 1 year VPA treatment compared with pretreatment. However, the serum level of testosterone was reduced 1 year after treatment (0.4±0.3 ng/mL) compared with pretreatment (0.7±0.4 ng/mL) and 3 months after treatment (0.7±0.4 ng/mL) (P＜0.05). CONCLUSIONS: VPA treatment for 1 year does not increase serum levels of androgen in adolescent girls with epilepsy, suggesting that VPA is an ideal choice of treatment for the girls.