早产儿血糖对定量脑电图参数的影响

Effect of blood glucose on quantitative electroencephalography parameters in preterm infants

摘要:

目的 探讨定量脑电图（qEEG）在评价血糖对早产儿脑功能影响中的价值。方法 选取2019年1~12月中南大学湘雅三医院新生儿科收治的早产儿为研究对象。根据血糖水平分为组1（< 4.95 mmol/L）、组2（4.95 mmol/L~）、组3（6.60 mmol/L~）与组4（≥8.55 mmol/L），比较各组间qEEG参数的变化，并对血糖与qEEG参数进行相关性分析。结果 共纳入早产儿39例，血糖测定采集点84个。与组4相比，其余各组各脑区总功率、额区和枕区各频带绝对功率均显著增高，差异均有统计学意义（P < 0.05）。各脑区总功率、δ/θ、（δ+θ）/（α+β）比值均与血糖呈负相关（P < 0.05），θ频带相对功率与血糖呈正相关（P < 0.05）。结论 随着血糖的改变，早产儿总功率、各频带功率及频谱组成均发生变化，qEEG可能成为监测早产儿血糖异常对脑功能影响的重要工具。

Abstract:

Objective To study the value of quantitative electroencephalography (qEEG) in evaluating the effect of blood glucose on the brain function of preterm infants. Methods The preterm infants who were admitted to the Department of Neonatology, The Third Xiangya Hospital of Central South University, from January to December 2019 were enrolled. According to the level of blood glucose, they were divided into group 1 (blood glucose < 4.95 mmol/L), group 2 (blood glucose 4.95 to < 6.60 mmol/L), group 3 (blood glucose 6.60 to < 8.55 mmol/L), and group 4 (blood glucose ≥ 8.55 mmol/L). The changes in qEEG parameters were compared between groups, and a correlation analysis was performed for blood glucose and qEEG parameters. Results A total of 39 preterm infants were enrolled (84 blood glucose measurements). Compared with group 4, the other three groups had significant increases in the total spectral power of each brain region and the absolute power of each frequency band in the frontal and occipital regions (P < 0.05). The total spectral power, δ/θ ratio, and (δ + θ)/(α + β) ratio of each brain region were negatively correlated with blood glucose level, while the relative power of θ frequency band was positively correlated with blood glucose level (P < 0.05). Conclusions With the change in blood glucose, there are significant changes in the total spectral power of each brain region, the power of each frequency band, and the frequency spectrum composition on qEEG in preterm infants. qEEG may therefore become an important tool to monitor the effect of abnormal blood glucose on brain function in preterm infants.