B细胞淋巴增生性疾病中微小残留病检测的新进展

Latest advances in minimal residual disease evaluation in B-cell lymphoproliferative disease

摘要:

在许多恶性血液系统疾病中，癌细胞清除率均与疾病预后息息相关。临床研究表明，微小残留病（MRD）可直接反映癌细胞清除率的高低，但目前用于MRD检测的工具仍有待完善。该综述介绍了数字聚合酶链反应和二代测序技术在B细胞淋巴增生性疾病MRD检测中的应用进展。

Abstract:

The clearance of cancer cells is closely associated with the prognosis of various hematologic malignancies. Clinical studies have shown that minimal residual disease (MRD) can directly reflect the clearance of cancer cells, but the tools for MRD detection need to be improved. This article reviews the latest advances in the MRD detection by digital polymerase chain reaction and next-generation sequencing in B-cell lymphoproliferative disease.