染色质重塑在小儿神经发育障碍中的遗传学机制进展

A review on the genetic mechanism of chromatin remodeling in children with neurodevelopmental disorders

摘要:

神经系统发育受到外在环境和内在信号的调控，除转录因子外，表观遗传修饰也发挥着重要作用。该文主要围绕ATP依赖的染色质重塑在小儿神经发育障碍中的遗传学机制展开，详细论述4大染色质重塑复合物家族对神经发生、神经元及神经胶质细胞发育成熟的影响，介绍神经发育障碍的临床研究进展。

Abstract:

Neural development is regulated by both external environment and internal signals,and in addition to transcription factors,epigenetic modifications also play an important role.By focusing on the genetic mechanism of ATP-dependent chromatin remodeling in children with neurodevelopmental disorders,this article elaborates on the effect of four chromatin remodeling complexes on neurogenesis and the development and maturation of neurons and neuroglial cells and introduces the clinical research advances in neurodevelopmental disorders.