Nasal decongestant is known to relieve nasal congestion rapidly and effectively. However, overdose and long-term use of nasal decongestant may cause rhinitis medicamentosa. Currently, there are still some controversial issues in the clinical use of nasal decongestant and management of rhinitis medicamentosa. For this reason, the Chinese Rhinopathy Research Cooperation Group convened domestic young and middle-aged rhinology experts to formulate an expert consensus on clinical use of nasal decongestant and management of rhinitis medicamentosa based on clinical experience and evidence-based medicine. This consensus systematically summarizes the relevant issues in order to guide and standardize clinicians to use nasal decongestant and treat rhinitis medicamentosa.