中草药对多重耐药菌的抑制作用及机制研究进展

Research progress in the inhibitory effect and mechanism of Chinese herbal medicine on multidrug-resistant organism

摘要:

抗菌药物的过度使用和滥用导致了多重耐药菌的出现。多重耐药菌感染日趋严重, 治疗困难, 迫切需要寻找多重耐药菌感染治疗的新型药物。中草药是我国特有的天然资源, 具有耐药性低、毒性低、价格低廉等优点, 对多重耐药菌具有较好的抑菌效果, 且中草药能够通过多种机制发挥抑菌作用。本文收集整理了国内外相关文献, 从单味中药、中药复方、中药联合抗菌药物对多重耐药菌的抑菌作用及机制方面作一综述, 以期为抗多重耐药菌药物研究提供理论依据。

Abstract:

The excessive use and abuse of antimicrobial agents have led to the emergence of multidrug-resistant organism (MDRO). MDRO infection is becoming increasingly severe and difficult to treat, it is urgent to find new drugs for the treatment of MDRO infection. Chinese herbal medicine is a unique natural resource in China, with advantages of low drug resistance, low toxicity and low price, it has good inhibitory effect on MDRD, and can exert inhibitory effect through various mechanisms.This article collects and sorts out relevant literatures at home and abroad, and reviews inhibitory effect and mechanisms of single traditional Chinese medicine, traditional Chinese medicine compound, and traditional Chinese medicine combined with antimicrobial agents on MDRO, so as to provide theoretical basis for the research of drugs against MDRO.