Abstract:Objective To investigate the efficacy of endoscopic retrograde cholangiopancreatography (ERCP) in treatment of choledocholithiasis combining human immunodeficiency virus (HIV) infection.Method Clinical data of 12 patients with choledocholithiasis combining HIV infection treated by ERCP from September 2017 to July 2021 were retrospectively analyzed, the efficacy and precaution were found after integrating the relevant literatures.Result The removal of the stones by ERCP were successful in all these patients. 4 patients were placed with the stent in common bile duct, 8 patients were indwelled the nasobiliary duct, and then underwent cholecystectomy. There was 1 patient suffered pancreatitis after ERCP, which was improved after conservative medical treatment. There was no obvious perforation, bleeding and infection in all patient.Conclusion ERCP was effective for the treatment of choledocholithiasis combining HIV infection, however, we should be alert to special complication in patients. Furthermore, we should be paid attention to decontamination of endoscope and protection of nosocomial infection.