叶绿素类光敏剂在光动力抗肿瘤中的研究进展

Research progress of chlorophyll photosensitizers in photodynamic antitumor

摘要:

光动力疗法（PDT）是一种多学科交叉融合发展起来的肿瘤治疗方法，光敏剂（PS）是光动力疗法中的重要作用因素。其中，叶绿素类光敏剂包含叶绿素及其衍生物，具有优良的光物理性质，是一类很有临床应用前景的光敏剂，目前针对叶绿素类光敏剂的基础研究及临床应用研究也正在开展。本文拟就八大叶绿素类光敏剂的特征、临床应用及研究进展进行综述。

Abstract:

Photodynamic therapy (PDT) is a multidisciplinary tumor treatment method, while photosensitizer (PS) is an important factor in photodynamic therapy. Chlorophyll photosensitizer, including chlorophyll and its derivatives, has excellent photophysical properties, so it is a kind of photosensitizer with promising clinical application. At present, the basic research and clinical application of chlorophyll photosensitizer are being carried out. In this article, we mainly reviewed the characteristics, clinical application and research progress of eight chlorophyll photosensitizers.